ELANE anticorps (AA 13-39)

N° du produit ABIN3030798

Cet anticorps anti-ELANE est un anticorps Lapin Polyclonal détectant ELANE dans ELISA et WB. Adapté pour Humain.

Aperçu rapide pour ELANE anticorps (AA 13-39) (ABIN3030798)

Antigène: ELANE (Elastase, Neutrophil Expressed (ELANE))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ELANE est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-ELANE anticorps

Épitope: AA 13-39

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 13-39 from the human protein was used as the immunogen for this Neutrophil elastase antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Neutrophil elastase antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Neutrophil elastase antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur ELANE

Antigène: ELANE (Elastase, Neutrophil Expressed (ELANE))

Autre désignation: Neutrophil Elastase

Sujet: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

UniProt: P08246